The Role and Significance of Polymorphisms of Certain Genes in Patients with Abdominal Aortic Aneurysm

INTRODUCTION: To date, many factors that influence the risk and course of abdominal aortic aneurysm (AAA) are not studied. Increasing significance in etiology development AAA is assigned to existence some genetic polymorphisms, role them studied either.
 AIM: analyze association with gene polymorphisms (GPs).
 MATERIALS AND METHODS: Gene were analyzed 20 patients (study group, SG); 18 men (90%) 2 women (10%), mean age 68.1 7.3 years), 5 without (control CG; 4 (80%) 1 woman (20%), 64.2 7.2 years). The frequency concomitant diseases for determined. following GPs studied: : Lys198Asn EDN1 gene; C-786T NOS3 Leu28Pro APOE Val174Ala SLC01B1 Thr715Pro SELP C807T ITGA2 Ser447Ter LpL Thr174Met AGT Met235Thr gene. Statistical analysis was performed using IBM SPSS Statistics 21, correlation ― according Pearson. results considered statistically significant at p 0.05.
 RESULTS: In SG, relationships identified polymorphism gene: direct (r = 0.63; р 0.001) gene, 0.70; a reverse relationship С786Т -0.35; 0.006) same amount found besides there also along has an additional 0.55; 0.40; 0.002) With this, 0.33; 0.011) gene.
 CONCLUSION: correlations been established, which indicates their probable this pathology may be used as screening test determination likelihood its development.